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1. Critique of "Stenting versus aggressive medical therapy for intracranial arterial stenosis" by... 2012

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bi9NAFB5cBfFl8YZ3OSz6VGIz02SawLJQyi4rIoKtz8tMZsaWtdvFTRH9IT75Yz1nLtlQV1F8CSVThiHflzPfnJwLYy_yxpXK4LHECmWyolYq0yM9ygpXVbosjVS82XLmfE-5MFdGsQ__G1q8h-BSquw_wNtNijfwN4KMV4QZr38FtG9WQEVYUfa9FGLW2tD8geItNhcD9dGfqClAaBU_yoScqxCpuSTnboMbFnnOfXxnyCChGuJUfkCQPp0uENEvy_bbwHuIU2wkKvLUBGTQE7Zv-5_ro-6dtZ_Xp17O8nqc990Per3JpgurP6V0m87nQ304V9b3m6XdcbVpF30fBQV7dPEeNtpVUWSUBts3vKE-UySY6FlRGdIvf7Xukqz7bP7-3ZvDyfGEzP0rSSfQUf_vCM_5yoMtqFqeDG0D_zy6VXM7De2wHTRoJLJfH3X7O4qcMiZh4oKGVy2HSkzHKbaOK162zG-z3QgLTAJv7rBr9uwuu5kgusd-JPrA2sFeIg8E8sAleSCSByJ5AMkDffJAIg8k8uyB_goddcC2gIPLM9hfHOAkgOyByB5Iy8Q1pKXtDxcH99mHo8P59DiLHTuyZlSJNpO-wqOQqnDccDHmyhbcNIrXFcpmk9vSaF3wSmuURc0459qhwm4aFJkVl46Lhwy4Uba0jZR5UxeqdBqZWRhnc2lqVzrxiD0ID_TkPNRjOUmP-vFvR56wW5e0fMpuOHz37TN2nQzMc4_uTwVVeDA

   Abou-Chebl, Alex; Steinmetz, Helmuth

   Stroke (1970), Vol. 43, Issue 2, p. 616.

   Symptomatic intracranial stenoses are an important cause of stroke and have a high risk of recurrent stroke with medical therapy. The Stenting and Aggressive Medical Management for Preventing Recur... Read more

   Symptomatic intracranial stenoses are an important cause of stroke and have a high risk of recurrent stroke with medical therapy. The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Arterial Stenosis (SAMMPRIS) trial unexpectedly showed a higher-than-expected rate of complications with intracranial stenting and a lower-than-expected recurrence rate with medical therapy. In this commentary, the authors review possible explanations for these findings and suggest future strategies for study. Read less

   Journal Article

2. Home institution bias in the New England Journal of Medicine? A noninferiority study on citation... 2018

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9UwFD_o9uKLc1O0OkcEBT-oa9KkTWFMLuqQC4oPbq8hTdPdMmxl3QX_fHPStHdlQ9hDoSQhn-ecnOSc_A7A68TUQlfuWGKZrmJeaB2XaZnGvJayFKLKNDXzyxxg09VFe_FxtEh6Qb1560YpOkpSBBaQPM7vw7Zwex9GLZCny0n6Oor10pd6Rk4nS-ZtVcz3ohsK5k0_yclYeh1YlIXN6GRniLjaewzD7i8-U5o54x96AESPenEN7PEOQ34ED4OaShYDXe3CPdvuwc4YAoIEibAHu-GvJ28DgPW7x_AbY6-TJrghuIUnZaN7l0COVsdO4SROspIQPYSMTXU1-R7s_EeHq-NPZEFavCquHYt0GGGPeCRc4mozAVecIMxF_wROT77--vwtDmEdYiMkvYpp5Y5cwiRVUUpZy5IXRtSMVnlqE204vljRlTGZNTZLDWUmTzKTU1NyxvD8lz4DQitthTVZlpiCa1GXTFJe1TbJqqJ2tUXwflxZ9WeA7VAbgGacVuWmVeG0qjyC_XHtVeDgXqGXgMS-8AheTdmO99CgolvbrX0Zpx07qScjeDqQytQaKwTLnT4WQT4joqkA4nrPc9pm5fG90ZJNWRLBh5EsNt36zyDeDBQ5a-BLc7ZQ3eW5Wq9VKlBdjIDdUg53axXSLxr8VG8VTRGeSvLk-Z268gIeuJmRw0XVPmxdXa7tS9hCNjjwzHoA2z9-ni2X_wCFxz_c

   Falk Delgado, Alberto; Falk Delgado, Anna

   Scientometrics, Vol. 115, Issue 1, pp. 607 - 611.

   Recently, in the four top journals of humanities, an institutional bias towards publication of authors from Harvard and Yale was shown. The New England Journal of Medicine (NEJM) is today the highe... Read more

   Recently, in the four top journals of humanities, an institutional bias towards publication of authors from Harvard and Yale was shown. The New England Journal of Medicine (NEJM) is today the highest ranked general medical journal. It is unknown if there exists institutional bias favoring publication of articles originating from Harvard University, since the NEJM is produced by the Massachusetts Medical Society with close connections to the Harvard University. We examined if studies originating from the Harvard University published in the NEJM were noninferior in terms of citation rates compared to articles with an origin outside Harvard University. We evaluated original research articles published in the NEJM in 2000 up until June 2001. A two-sample noninferiority test based on the primary endpoint of citations was performed. Twenty-two studies were affiliated to the Harvard University and 280 studies were not affiliated to the Harvard University. The mean number of citations for Harvard affiliated studies was 625 (95% CI 358–952, median 354) and for non–Harvard affiliated studies 493 (95% CI 421–569, median 303). The mean difference was not statistically different between affiliations, but fulfilled the requirements for noninferiority [132 (95% CI − 138–402, P  = 0.343), Δ 200]. In summary, citation rates were comparable between studies origination from the Harvard University compared to non-Harvard Institutions. Based on these results there appears to be low risk of institutional bias in the publishing process of original studies in the NEJM. Read less

   Journal Article  |  Full Text Online

3. The Use of Statistics in Medical Research 2007

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwED6hTmXgUUCEQuWBpUNEYseOI7EgRMQAW5HYIj8FS0Gk_H9sJ24bBEvXyLFsf-c7n-_8HcB1piwV2rklBgudFpUQqSSSpIXlXFKqmcjV8DIHbuNbGJ9W6X1o2xFFBF3tN7eQfQWSivvHB8RHYcrXvPQmxilgt9-9kC_qp40aLhmO5fJcaxpjlH90MLBJA8bSmKXoUyZF61bNduUuhpqb9OaoPoS3OJGQheJrH2yn498ECsTAexHpHned9BEc9EdWdNfJ2DHsmeUE9p_XfK_tBMb-zNpRPp_A3IkeemkN-rBo8x29L1EfFUIx3e8UFvXD4v4x7SsypIrQbJUaKoVU0vDK4YsJJZppptxHwZwwZFQ7j7dguTYFs04bGOsQdwc8rSurbGnJOaBcC0ONYixTVSGolZjnhbYmY64RtTiBecSi-ewIN5rgqFS8-b0GCRTbYDWrcMnRQ9SQ_387C6Cu-8cl84ytZQKzAcqbATgb7rVhAtMIe9Pv9bbBmPtoKc8vdhvOFMbdhbHPkbmE0err21zByMvMLPAVz4Jg_wA3B_Zy

   Strasak, Alexander M; Zaman, Qamruz; Marinell, Gerhard; Pfeiffer, Karl P...

   The American Statistician, Vol. 61, Issue 1, pp. 47 - 55.

   There is widespread evidence of the extensive use of statistical methods in medical research. Just the same, standards are generally low and a growing body of literature points to statistical error... Read more

   There is widespread evidence of the extensive use of statistical methods in medical research. Just the same, standards are generally low and a growing body of literature points to statistical errors in most medical journals. However, there is no comprehensive study contrasting the top medical journals of basic and clinical science for recent practice in their use of statistics. All original research articles in Volume 10, Numbers 1-6 of Nature Medicine (Nat Med) and Volume 350, Numbers 1-26 of The New England Journal of Medicine (NEJM) were screened for their statistical content. Types, frequencies, and complexity of applied statistical methods were systematically recorded. A 46-item checklist was used to evaluate statistical quality for a subgroup of papers. 94.5 percent (95% CI 87.6-98.2) of NEJM articles and 82.4 percent (95% CI 65.5-93.2) of Nat Med articles contained inferential statistics. NEJM papers were significantly more likely to use advanced statistical methods (p < 0.0001). Statistical errors were identified in a considerable proportion of articles, although not always serious in nature. Documentation of applied statistical methods was generally poor and insufficient, particularly in Nat Med. Compared to 1983, a vast increase in usage and complexity of statistical methods could be observed for NEJM papers. This does not necessarily hold true for Nat Med papers, as the results of the study indicate that basic science sticks with basic analysis. As statistical errors seem to remain common in medical literature, closer attention to statistical methodology should be seriously considered to raise standards. Read less

   Journal Article  |  Full Text Online

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