Search All

Articles

1. LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at... 2021

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZoD4gL4iVYaKtB4sCBdJP4lfRGK1oOjajaLuIW-RU1aJOstlkhDvx3xt5k2wWJA5dRZDtOlBnH39gznwl5R5l1soptZBCNRowZGWmhksiDBcGSylGptxdzCB9zYULQvtH1YTtvDtv6JsRWLhozHePEphfFCYL8PMnEdIfsSMruuejh98t4znk6MAwlVEx1890fRYUGkaLr7Bnn_EyCpdtz0V8A8884yXsTz-kT8nhAjPBx_WZPyQPXPiMPi2FP_Dn5dT4rvlxBBOfdD1CthbDIFzJCegdnS2VRzuuuUTBr0AFGvYOPHvwJXQXFeDounK1q6yxch3ys2l2B6sEnuixu3RFcLLu-Q5MBhLigYFHPux4CM-0LMjv9dH3yORoOVYg0k7SPEAFQl1eZNJYnKtZMCWMSnVZWKIneBc2FEZ6HMM0Vy3KumYvxygMTz-2W0FcEmGTGl_LM5gin8gwnWkoFrbgV3Go7Ie_x65bDaLgtg6NBRTkoovSKKNeKmJAPowrKxZpf49_N90Y13XWPTiBWxnkmJuTtphqHid_7UK3rVtgmSxj63DLDLl6utbp5HpUetKRyQuSWvjcNPAX3dg1aZqDiHizx9X_f-YY8CmbpqSPjPbLbL1dun-z6_I0DtO7Lr15-k0EeoyziSy_T4iBY_W_EgAMm

   Kong, Benjamin Y; Sim, Hao-Wen; Nowak, Anna K; Yip, Sonia...

   Bmj Open, Vol. 11, Issue 12.

   IntroductionGrades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal... Read more

   IntroductionGrades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet there is a paucity of trials for Australian patients with relapsed G2/3 gliomas compared with patients with GBM. LUMOS will be a pilot umbrella study for patients with relapsed G2/3 gliomas that aims to match patients to targeted therapies based on molecular screening with contemporaneous tumour tissue. Participants in whom no actionable or no druggable mutation is found, or in whom the matching drug is not available, will form a comparator arm and receive standard of care chemotherapy. The objective of the LUMOS trial is to assess the feasibility of this approach in a multicentre study across five sites in Australia, with a view to establishing a national molecular screening platform for patient treatment guided by the mutational analysis of contemporaneous tissue biopsiesMethods and analysisThis study will be a multicentre pilot study enrolling patients with recurrent grade 2/3 gliomas that have previously been treated with radiotherapy and chemotherapy at diagnosis or at first relapse. Contemporaneous tumour tissue at the time of first relapse, defined as tissue obtained within 6 months of relapse and without subsequent intervening therapy, will be obtained from patients. Molecular screening will be performed by targeted next-generation sequencing at the reference laboratory (PathWest, Perth, Australia). RNA and DNA will be extracted from representative formalin-fixed paraffin embedded tissue scrolls or microdissected from sections on glass slides tissue sections following a review of the histology by pathologists. Extracted nucleic acid will be quantified by Qubit Fluorometric Quantitation (Thermo Fisher Scientific). Library preparation and targeted capture will be performed using the TruSight Tumor 170 (TST170) kit and samples sequenced on NextSeq 550 (Illumina) using NextSeq V.2.5 hi output reagents, according to the manufacturer’s instructions. Data analysis will be performed using the Illumina BaseSpace TST170 app v1.02 and a custom tertiary pipeline, implemented within the Clinical Genomics Workspace software platform from PierianDx (also refer to section 3.2). Primary outcomes for the study will be the number of patients enrolled and the number of patients who complete molecular screening. Secondary outcomes will include the proportion of screened patients enrolled; proportion of patients who complete molecular screening; the turn-around time of molecular screening; and the value of a brain tumour specific multi-disciplinary tumour board, called the molecular tumour advisory panel as measured by the proportion of patients in whom the treatment recommendation was refined compared with the recommendations from the automated bioinformatics platform of the reference laboratory testing.Ethics and disseminationThe study was approved by the lead Human Research Ethics Committee of the Sydney Local Health District: Protocol No. X19-0383. The study will be conducted in accordance with the principles of the Declaration of Helsinki 2013, guidelines for Good Clinical Practice and the National Health and Medical Research Council National Statement on Ethical Conduct in Human Research (2007, updated 2018 and as amended periodically). Results will be disseminated using a range of media channels including newsletters, social media, scientific conferences and peer-reviewed publications.Trial registration numberACTRN12620000087954; Pre-results. Read less

   Journal Article  |  Full Text Online

2. The Influence of Distress on Knowledge Transfer for Men Newly Diagnosed with Prostate Cancer 2012

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dS9xAEB-sghTE1g80ao8VfLKs5vYjmzxaW_HrUNoqfRBCkt0FUXJyKuh_78wmOT3aPvgyELLkY2d25rczOzMAW1JZZ3xseYVolCtVGV4mRZ8TWEhU3ztpyklnDoix66K-2ekikkFRv-a6ofTRKUnBY6kkR7U7o9H2UdeC9OJ4HDnQojm2mKaaU4yoi2T-6xGTtugvgDkZHBWtzTn41DRWvQ-lCodPlI00ceZ-N9Q5DMUt3tR0fMeffYb5Fo2yvUZ8FmDK1YswO2jj7Ysw13j1WJOstARXKFXsqOtrwoaefb9usk3YsGYnnX-OBQvo3YghJGYDVzPUpbfPODic63OWkfuXnVPGCWJdtk-iN1qGi4Mfv_cPedufgVcy0w_IVGF9LAtvjU3SCpFa6lPjcE33PfWlLF0hs7jQOFjLxHqvbF9WuEOrSo9Ip5SrwJRRlYuzQqc2Q2SWpWizpUyk1zbRtrQRbHcsyu-a-hv5a6VlmrgcJy6nictFBBsdE_N2Kd7T3gbFREmjI9gc38ZFRJGRonbDRxwTI0wMfbwiWGmYP34bKjyB274sgq8d-948_H-fsvau0evwUQT-k3dnA6YfRo_uC0yTRPXgg_l5SfSPCfRbLwh8D2b2Tn-dHuHVID4nKgaBnr0ABOX6kw

   Hovey, R. B.; Cuthbertson, K. E. S.; Birnie, K. A; Robinson, J. W....

   Journal Of Cancer Education, Vol. 27, Issue 3, pp. 540 - 545.

   The purpose of this inquiry was to evaluate the efficacy of prostate cancer education sessions. Implementation of 3-h patient educational sessions was intended to provide men newly diagnosed with l... Read more

   The purpose of this inquiry was to evaluate the efficacy of prostate cancer education sessions. Implementation of 3-h patient educational sessions was intended to provide men newly diagnosed with localized prostate cancer, who face difficult and complex decisions, information about potential treatment options. Fifty-seven men completed the distress thermometer assessment before the education session to assess baseline levels of distress. Seven of the men were interviewed post-educational session to determine the degree of knowledge transfer from the session. This study explored the efficacy of the patients’ learning experience using an interpretive phenomenological research approach. Resulting data revealed that these patients, as adult learners, were distressed and that, despite the availability of pertinent medical content, the subject material was not learned as intended or readily understood. The conclusion drawn from this preliminary applied educational research study was that the education model used was less than efficacious at ensuring that sufficient knowledge transfer was achieved for medical treatment decision-making processes. These findings suggest a need for future research to explore the application of adult learning theories and approaches that may offer enhanced knowledge translation and transfer for prostate cancer education programs. Read less

   Journal Article  |  Full Text Online

3. Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene 1995

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB6aQCCX0id1krY69Opd2XpZxxC69FIITe5CsuR2Q9cOdRaa_vqOLHnBpb30YmwkgT0PzTfW6BPAB8Z9UB31ZYtotOS8VaWTtiojWJC86gJTbvkzJ20KG3NZZd-67ar_vlv1229TbeX9rl3PdWLr689XlZKqpusjOFKMzxl6XjngXGSG8AodWbNc04XT8PrOrSqlVgKfpC6rSjVxr544hRPVRBr2ZhmbZr7gv2HPP0soE8HUFJM2z-BpBpPkMr30c3gS-hdwko6XfHwJX6ZANE8L2NFmBhIydASBH7kew94PaIh2JDb82H_d9sNoSfg5hP7X4y6QG5L4ZSM3B0FTC6_gdvPx9upTmc9QKFtB6UPpMIEKbR089x1rudUBPxWdUDKrJNWNUKgr6x2GKBfBipdOdpQrhCk0UM3eAOGKt3hrReM1gifdYFhlTLJOeCm88wXQWWrmPlFkmCm1qBtz50wkExcmijwSizcmiryAs1m6xo67ZbcCzmd5m-xQo6lrFTnO49D3h1b0hLi8Yfsw7EdTSUy4NW_-3UMpnN-llgW8Tto7vG82gALkQq2H9kjCvWxB25zIuJMtnv3vwHM4TZvkY1XbBRyjUsNbOI77N95Nhh2vN5vfipH9oA

   Yahr, T L; Hovey, A K; Kulich, S M; Frank, D W

   Journal Of Bacteriology, Vol. 177, Issue 5, pp. 1169 - 1178.

   Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue ... Read more

   Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JB About JB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0021-9193 Online ISSN: 1098-5530 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JB .asm.org, visit: JB        Read less

   Journal Article  |  Full Text Online

See all 10 article results