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1. Characterization of serum levels of testosterone and corticosterone in a blast and amputation rat... 2020

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSwMxEB5EQbz4aEXriwjiQVzcZh_pHuujKKInBW8hySao2N2i24Nn_7gz2W5RURGP2Uceky_JJPNlBmAvd1qHXZUHJuIqiFXqgl7WdYEVFleLvMudyz8f5sBhcxfmqwnfU7GGhhxacs9ZFxnd1osSQXEaBqfH02lXJD6QKoI2CgQPRWPC_C6Hnxahn5RMv9gMluCuqabnmFBkg49k-yPv4NB7tWicOf61ScuwOFFAWb9GzArM2KIF7X6Bm-_hK9tnnhLqz9pbMH81sby34e1k6tm5vrjJSscQvuMheyLe0QulKwpTQ54XysIyVeQMt7ZYzPTRQ8EU06ivV_6tooASdWaIQ-aD8lA290TRKaty9GAYio_ITP6rVbgdnN2cnAeTAA7Y81laBV2D80HKwySPeiHXkeGOOwQN7_XIJ4HjOsycjnScuMQJinyS6DhNdYizjAgzG60Dc9xmuTAqMsLFhgttYmVtnCKIUmNT0YGDpivlqHbQIRvm2qNEMUsSs6zF3IG46Ww50TBqzUFiD_32224DDImjj0wqqrDl-EWiwkOW2CSLO7BWI2ZaC2wEWZn5xv8K3YQFStW0tC2YrZ7HdhtmCWw7MNe_uDy_3vEj4B0S6QSl

   Qin, Mack Y.; Atwood, Rex E.; Ketchum, William A.; Kaba, Stephen A....

   Molecular And Cellular Endocrinology, Vol. 509, p. 110799.

   Endocrine dysregulation's role in heterotopic ossification (HO) remains unexplored. We sought to examine corticosterone and testosterone in established rat models of ectopic bone formation, and cor... Read more

   Endocrine dysregulation's role in heterotopic ossification (HO) remains unexplored. We sought to examine corticosterone and testosterone in established rat models of ectopic bone formation, and correlate to HO formation with CT analysis. Fifteen rats were placed into three groups of traumatic injury patterns: Blast and injury (120 kPa blast, femoral fracture and quadriceps crush), injury only, and blast only. Serum corticosterone and testosterone levels were drawn until post-operative day 40. HO was analyzed using CT. Corticosterone levels peaked in the blast and injury group in the shortest time post injury, followed by injury only and blast only groups. Testosterone levels reached nadir in similar fashion. Volume of HO was highest in the blast and injury group, followed by the injury only group. Corticosterone and testosterone's contribution to HO formation requires further characterization, but this study suggests that high peaks in corticosterone and a low nadir in testosterone are associated with higher volumes of HO. •We evaluated levels corticosterone and testosterone in a model of heterotopic ossification (HO).•Corticosterone and testosterone levels follow similar patterns seen in traumatic blast injury.•High peak corticosterone levels and low nadir testosterone levels occurred in rats with the most HO. Read less

   Journal Article  |  Full Text Online

2. Poster 428 The Peril of Antibody Testing for Heparin-Induced Thrombocytopenia: A Case Report 2014

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV05b9swFCZaZ-nSG6h7gUM3Q6kOWjK7GUHadGhhNOpWgOCJxkDswHaG_Pu-Jz4qihMUPRZBJiCT4vv4Lr2DsXcuGJMX2mW2KnUmdB2ymSxC5hsP0sIVZQhuz5nzLeXC3BnF_v6_SQtjQFxMlf0L8vZ_CgNwD0SGK5AZrn9EaGy36zcTUPC78IkFzBn1y9XuzKzd1aTFQhoUL3nisevgKsOOHfjlv_25WZ-btb3aYRutM02J6iDaSDUfKq-LLx1Q-m9D1ImZXDbXrBuAcJlghqbzdnJ0OPQuFKIPnyKXV0p7uRGVCUqfyLCAaBQig7EpcStirfUAQXLAJk-rWKOERG76eYudR8_C8vDifLPEMDyB5VZntL6bZbJPcQG4JrQY0a69zw7KRspyxA7mx58_fU3yuRZF1_-zfwlKpYpRf_sz3a2uxFjZTgVpH7OHZDvwecTAE3bPr56yRws6abyNBSKesR8REhwggYO8gwRfB54gwQkSHCDB9yDB9yHxgc85AoJHQDxn3z8et0cnGXXRyGwXL-dAyUWlspZO6CCFqbwUpfFgJ2jthYHbOg9aWi-nzoP9MAuFqcGQtbkB87apXjAeSi9dY3VlmyBs2RgrtPeihpNcW183YzZJu6QuYpUUlcIHlwr3VOGeqnymYE_HrEkbqVL-L0gsv6VTtVWF2pYqV7doOmbT_knSEKPmpwAxv5nx5T8-94o9uD4Ur9lot7n0b9gI-dJbgtUv1imGbA

   Kim, William, MD; Ketchum, Nicholas C., MD

   Pm & R, Vol. 6, Issue 9.

   Journal Article  |  Full Text Online

3. Factor analysis of persistent postconcussive symptoms within a military sample with blast exposure 2015

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZaeuGCgCKgPORDyyWKmjh-NEdUdVXaW7UV3CrHDwmJbKJNeii_iR_JOLY33lIQiByiKFaiKPNlMv488w1Ch9o2TVFKnauKyJxKbvOTurS5EQb-Frok1up7ZM6PWAvzYBb78X-bFs6BcV2p7D-Yd3NTOAHHYGTYg5lh_1eGXkwdczKZqIv0jgQD863GrO-GEaa86naY8tSHu7Yfu9bXtH1dZTJrJ5nu9V02SCcU7InZBmLq0an_d0NQHIkBrINVojYBrly7NhO3rczWW6LfG2C4rvAmlmDLmX09_S7Xq84Hry7HRs6rQpcOS74B84VL01XJZZ_lt5AIEqiiwPMG5qJkCXNhgrdlRQ4Ry5fUHYdlmhR23reeedbzF5_vtYTPl1dei3KzedWuBAF9O0GAUF4z4puA_Hn0nhJ3HNpFu-DmXOj9aTGvWImSxdLMWhw_9DhOeDrcIp3EVCGYWT5FT8IsBH_0aHqGdszqOTpKFafx0stN4A_4asuu-6jxiMMRcbizeEYc3kYcjojDHnFY4og47BE3DeAJcTgi7gW6XpwtT8_z0KojVxCBj7klBSsk4bYsK0MnsVnKG6GZpZXQUrNSn1imCtZUNRdUClNpzpva9RipRW3IK4QtMbUWSlZKWKqIaBSVxlAO7oIrw8Vr9NK_s5veC7HcxLd58NuRN-jxjLy3aM_CR2_eoUfOs7yfDPgTu7t51A

   Franke, Laura M; Czarnota, Jenna N; Ketchum, Jessica M; Walker, William C

   The Journal Of Head Trauma Rehabilitation, Vol. 30, Issue 1.

   To determine the factor structure of persistent postconcussive syndrome symptoms in a blast-exposed military sample and validate factors against objective and symptom measures. Veterans Affairs med... Read more

   To determine the factor structure of persistent postconcussive syndrome symptoms in a blast-exposed military sample and validate factors against objective and symptom measures. Veterans Affairs medical center and military bases. One hundred eighty-one service members and veterans with at least 1 significant exposure to blast during deployment within the 2 years prior to study enrollment. Confirmatory and exploratory factor analyses of the Rivermead Postconcussion Questionnaire. Rivermead Postconcussion Questionnaire, PTSD (posttraumatic stress disorder) Symptom Checklist-Civilian, Center for Epidemiological Studies Depression scale, Sensory Organization Test, Paced Auditory Serial Addition Test, California Verbal Learning Test, and Delis-Kaplan Executive Function System subtests. The 3-factor structure of persistent postconcussive syndrome was not confirmed. A 4-factor structure was extracted, and factors were interpreted as reflecting emotional, cognitive, visual, and vestibular functions. All factors were associated with scores on psychological symptom inventories; visual and vestibular factors were also associated with balance performance. There was no significant association between the cognitive factor and neuropsychological performance or between a history of mild traumatic brain injury and factor scores. Persistent postconcussive symptoms observed months after blast exposure seem to be related to 4 distinct forms of distress, but not to mild traumatic brain injury per se, with vestibular and visual factors possibly related to injury of sensory organs by blast. Read less

   Journal Article

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