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1. BMC Clinical Pathology Reviewer Acknowledgment 2015 2016

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NS8NAEB1sD-JF_AKrteQgCEKaZLNJNlIKtVi8FHpQ8Bb2q7TQxtJWqP_e2c1GzNXzJiTMTubNzL55AbhXAiNgwjM_TajyqRYYB833iMhAo4gniknSbOZAUs_CWNK-FMt-uVr3y-XCcis3axnUPLFgNh1TTHLDnAUtaGUxrUt0d3SQIWS548uIpcHONFoMuxILZ8Qj_9AAIBeGm3zIPwAzOYNTlxl6o-oNzuFIlxdwPHVn35fwNFgMn6djzyl5rrwZ39vQ9T0IFkOvavLrrTeSdZ_MNP48hN7kCt4nL2_jV9_9-cCXJMwOvjQzzVQjeDPBQ6YFS6lKFOZqKlc5UVxg1qXj1Iqrz2WWyLnGOoJrLHRFTNP4Gjym80hgrcniCNdyykMjzkYEYUqwOFYdeKztUGwqZYvCVgQsLSqjFYb9ZYxWHDrwYCxVGK9HE0nuyPufpTb6UcWIGiV7TP9YB7qNK9FbZWM5a9j699FG5rq5grtv5a7dbt_8-85bOCF2_4kfsS6099svfQdtMyPRQw_6yHrWg34AStfJrA

   Zhang, Elaine

   Bmc Clinical Pathology, Vol. 16, Issue 2.

   Contributing reviewers The editors of BMC Clinical Pathology would like to thank all our reviewers who have contributed to the journal in Volume 15 (2015).

   Contributing reviewers The editors of BMC Clinical Pathology would like to thank all our reviewers who have contributed to the journal in Volume 15 (2015). Read less

   Journal Article  |  Full Text Online

2. BMC Clinical Pathology reviewer acknowledgement 2014 2015

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PS8MwFA5uB_Ei_kKnc_QgeMrapEmT4hjM4fAy2EHBW8mvscE2x5gH_3tf2rTQq-ekpLy8vO-95MsXhJ6shgjIlcAZZxYzpyEO-vUIyMAIUdxKQ9ubOYjXd2FK0r7R6-Fusx3u1quSW7nfmrjmicWL-ZR5lTVC4w7qiJTVJXo4OhAAWUGdkcgsJkxQnMk8wYRj0kKfEIMb5GmzIis-ZAkzswt0HvLDaFL9xyU6cbsrdDoPJ-DX6GW0Gr_Op1HQ89xEC3UsA9jvKF6No-omijtEyjS7ZX7_LwIEZjfoc_b2MX3H4QEEbGCpEeyUFlQxIpSAlWmZTZwhS64SY-VS5cmS2oRTqSHJYIwmOheaWJHl3OcFRuj0DkXS5URDySlT4gB7mEq8RhvVVFot09T20HNtkWJfCVwUZWEgs8LbrvC2KwgvCPT0Biu854OBjAoE_u-d8xpSxcS_KM4gAeM91G_1BI81rebbytLNgL6MgzqT9pBozUHTwYtgt1vAN0ox7OAL9__-8gGdwRR4BiOmso-6x8OPe0Rdf4NiAP71JQalf_0BWGDSOw

   Morawska, Magdalena

   Bmc Clinical Pathology, Vol. 15, Issue 9000, p. 1.

   The editors of BMC Clinical Pathology would like to thank all of our reviewers who have contributed to the journal in Volume 14 (2014).

   The editors of BMC Clinical Pathology would like to thank all of our reviewers who have contributed to the journal in Volume 14 (2014). Read less

   Journal Article  |  Full Text Online

3. Cross-reactivity of steroid hormone immunoassays: clinical significance and two-dimensional... 2014

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB6aHEovJX3QOk2DCoX2onhlyZZUQiBdGnoJ9NBCb0avZQ1de0k2lFz7yzvjx7busRfbIBnLmhnNjDTzDcDb6HEFLJ3mVakiV8njOkjyiJpBCeHKaEIx38yBcsqF6YP2g2_O2h-bs7ZZ97GV203Ipzix_Mv1UpGRYER-AAdaqslFH48ONKqsEcNHmCoXShe8MnbBheKSyuYUZAKpvkLZH03073r8l0KaB0sOUFK99rk6gsej2cguh-E9gQepfQoPr8eD8Wfwa0nf4GgBhqEcBOtWjDAQuiayNdqlXZtYQ7kgHVrL7v72AztfX0xpkef5-oJRJAfFDREbMNdGtvvZ8Ujg_wNwB9tMlXSx66bBO31me0NjIOo-h29Xn74uP_OxvAIPaEPsuI19rWEhIop5pZOT3qzUyuvgy1i6FH0MtorO-SD1aqUTmoIhoH9RoJPhTSVfAjPJCo8OrZEioWZTbkEIcIUvTPRGypjB-2mO6-0An1H3boepaqJMTZTBp1rKDN4RDWoSLJzo4Mb8AJwfgqiqL0tpK2uV1RmczHqiQIR580TFehTI25qQ6OiMcGEzeLNvpjcpyKxN3d3Qp8J_sUUGLwai7wc9MU0GesYO-w4E0z1vQe7t4bpHbj3-7zdfwSM00xTtKAt1Aoe7m7v0Gg4px-MUJeC77q8fT3s5-A1ifQ23

   Krasowski, Matthew D; Drees, Denny; Morris, Cory S; Maakestad, Jon...

   Bmc Clinical Pathology, Vol. 14, Issue 1, p. 33.

   Immunoassays are widely used in clinical laboratories for measurement of plasma/serum concentrations of steroid hormones such as cortisol and testosterone. Immunoassays can be performed on a variet... Read more

   Immunoassays are widely used in clinical laboratories for measurement of plasma/serum concentrations of steroid hormones such as cortisol and testosterone. Immunoassays can be performed on a variety of standard clinical chemistry analyzers, thus allowing even small clinical laboratories to do analysis on-site. One limitation of steroid hormone immunoassays is interference caused by compounds with structural similarity to the target steroid of the assay. Interfering molecules include structurally related endogenous compounds and their metabolites as well as drugs such as anabolic steroids and synthetic glucocorticoids. Cross-reactivity of a structurally diverse set of compounds were determined for the Roche Diagnostics Elecsys assays for cortisol, dehydroepiandrosterone (DHEA) sulfate, estradiol, progesterone, and testosterone. These data were compared and contrasted to package insert data and published cross-reactivity studies for other marketed steroid hormone immunoassays. Cross-reactivity was computationally predicted using the technique of two-dimensional molecular similarity. The Roche Elecsys Cortisol and Testosterone II assays showed a wider range of cross-reactivity than the DHEA sulfate, Estradiol II, and Progesterone II assays. 6-Methylprednisolone and prednisolone showed high cross-reactivity for the cortisol assay, with high likelihood of clinically significant effect for patients administered these drugs. In addition, 21-deoxycortisol likely produces clinically relevant cross-reactivity for cortisol in patients with 21-hydroxylase deficiency, while 11-deoxycortisol may produce clinically relevant cross-reactivity in 11β-hydroxylase deficiency or following metyrapone challenge. Several anabolic steroids may produce clinically significant false positives on the testosterone assay, although interpretation is limited by sparse pharmacokinetic data for some of these drugs. Norethindrone therapy may impact immunoassay measurement of testosterone in women. Using two-dimensional similarity calculations, all compounds with high cross-reactivity also showed a high degree of similarity to the target molecule of the immunoassay. Compounds producing cross-reactivity in steroid hormone immunoassays generally have a high degree of structural similarity to the target hormone. Clinically significant interactions can occur with structurally similar drugs (e.g., prednisolone and cortisol immunoassays; methyltestosterone and testosterone immunoassays) or with endogenous compounds such as 21-deoxycortisol that can accumulate to very high concentrations in certain disease conditions. Simple similarity calculations can help triage compounds for future testing of assay cross-reactivity. Read less

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