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The Goldwater-Nichols DOD Reorganization Act [microform] : a ten-year retrospective / edited by Dennis J. Quinn.
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1999
Available at Available Merrill-Cazier Government Documents (Lower Level) (Call number: D 5.402:G 58)
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| Merrill-Cazier Government Documents (Lower Level) | D 5.402:G 58 | Available |
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Peace support operations and the U.S. military / edited by Dennis J. Quinn.
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1994
Available at Available Merrill-Cazier Government Documents (Lower Level) (Call number: D 5.402:P 31/3)
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| Merrill-Cazier Government Documents (Lower Level) | D 5.402:P 31/3 | Available |
Winners and Losers in International Trade: The Effects on US Presidential Voting
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71 Int'l Org. 423 (2017) / International Organization, Vol. 71, Issue 3 (Summer 2017), pp. 423-458
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Jensen, J. Bradford;Quinn, Dennis P.;Weymouth, Stephen
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71 Int'l Org. 423 (2017) / International Organization, Vol. 71, Issue 3 (Summer 2017), pp. 423-458
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The Influence of Firm Global Supply Chains and Foreign Currency Undervaluations on US Trade Disputes
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69 Int'l Org. 913 (2015) / International Organization, Vol. 69, Issue 4 (Fall 2015), pp. 913-948
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Jensen, J. Bradford;Quinn, Dennis P.;Weymouth, Stephen
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69 Int'l Org. 913 (2015) / International Organization, Vol. 69, Issue 4 (Fall 2015), pp. 913-948
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Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries
Mwayi Kachapila;Mark Monahan;Adesoji O. Ademuyiwa;Yakubu Momohsani Adinoyi;...
Background: This study assessed the potential cost-effectiveness of high (80–100%) vs ...
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Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries
BJA Open, Vol 7, Iss , Pp 100207- (2023)
Background: This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods: Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($). Results: High FiO2 may be cost-effective (cheaper and effective). In Nigeria, the average cost for high FiO2 was $216 compared with $222 for low FiO2 leading to a −$6 (95% confidence interval [CI]: −$13 to −$1) difference in costs. In India, the average cost for high FiO2 was $184 compared with $195 for low FiO2 leading to a −$11 (95% CI: −$15 to −$6) difference in costs. In South Africa, the average cost for high FiO2 was $1164 compared with $1257 for low FiO2 leading to a −$93 (95% CI: −$132 to −$65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion: High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this.
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abdominal surgery - cost-effectiveness analysis - global surgery - high fraction of inspired oxygen - low-and middle-income countries - surgical site infection - Anesthesiology - RD78.3-87.3Content provider:
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Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
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Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
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Lorna Ewart;Athanasia Apostolou;Skyler A. Briggs;Christopher V. Carman;Jake...
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Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
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Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. T...
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Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. They also perform an economic analysis to demonstrate its potential financial value for the pharmaceutical industry.
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MedicineContent provider:
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Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
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Communications Medicine, Vol 3, Iss 1, Pp 1-1 (2023)
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Lorna Ewart;Athanasia Apostolou;Skyler A. Briggs;Christopher V. Carman;Jake...
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Communications Medicine, Vol 3, Iss 1, Pp 1-1 (2023)
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Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
Communications Medicine, Vol 3, Iss 1, Pp 1-1 (2023)
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Two Warm Super-Earths Transiting the Nearby M Dwarf TOI-2095
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The Astronomical Journal, Vol 166, Iss 5, p 195 (2023)
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Elisa V. Quintana;Emily A. Gilbert;Thomas Barclay;Michele L. Silverstein;Jo...
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The Astronomical Journal, Vol 166, Iss 5, p 195 (2023)
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We report the detection and validation of two planets orbiting TOI-2095 (TIC 235678745...
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Two Warm Super-Earths Transiting the Nearby M Dwarf TOI-2095
The Astronomical Journal, Vol 166, Iss 5, p 195 (2023)
We report the detection and validation of two planets orbiting TOI-2095 (TIC 235678745). The host star is a 3700 K M1V dwarf with a high proper motion. The star lies at a distance of 42 pc in a sparsely populated portion of the sky and is bright in the infrared ( K = 9). With data from 24 sectors of observation during Cycles 2 and 4 of the Transiting Exoplanet Survey Satellite, TOI-2095 exhibits two sets of transits associated with super-Earth-sized planets. The planets have orbital periods of 17.7 days and 28.2 days and radii of 1.30 R _⊕ and 1.39 R _⊕ , respectively. Archival data, preliminary follow-up observations, and vetting analyses support the planetary interpretation of the detected transit signals. The pair of planets have estimated equilibrium temperatures of approximately 400 K, with stellar insolations of 3.23 and 1.73 S _⊕ , placing them in the Venus zone. The planets also lie in a radius regime signaling the transition between rock-dominated and volatile-rich compositions. They are thus prime targets for follow-up mass measurements to better understand the properties of warm, transition-radius planets. The relatively long orbital periods of these two planets provide crucial data that can help shed light on the processes that shape the composition of small planets orbiting M dwarfs.
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Exoplanets - M stars - Astronomy - QB1-991Content provider:
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The TESS Grand Unified Hot Jupiter Survey. II. Twenty New Giant Planets
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The Astrophysical Journal Supplement Series, Vol 265, Iss 1, p 1 (2023)
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Samuel W. Yee;Joshua N. Winn;Joel D. Hartman;Luke G. Bouma;George Zhou;Samu...
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The Astrophysical Journal Supplement Series, Vol 265, Iss 1, p 1 (2023)
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NASA’s Transiting Exoplanet Survey Satellite (TESS) mission promises to improve our un...
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The TESS Grand Unified Hot Jupiter Survey. II. Twenty New Giant Planets
The Astrophysical Journal Supplement Series, Vol 265, Iss 1, p 1 (2023)
NASA’s Transiting Exoplanet Survey Satellite (TESS) mission promises to improve our understanding of hot Jupiters by providing an all-sky, magnitude-limited sample of transiting hot Jupiters suitable for population studies. Assembling such a sample requires confirming hundreds of planet candidates with additional follow-up observations. Here we present 20 hot Jupiters that were detected using TESS data and confirmed to be planets through photometric, spectroscopic, and imaging observations coordinated by the TESS Follow-up Observing Program. These 20 planets have orbital periods shorter than 7 days and orbit relatively bright FGK stars (10.9 < G < 13.0). Most of the planets are comparable in mass to Jupiter, although there are four planets with masses less than that of Saturn. TOI-3976b, the longest-period planet in our sample ( P = 6.6 days), may be on a moderately eccentric orbit ( e = 0.18 ± 0.06), while observations of the other targets are consistent with them being on circular orbits. We measured the projected stellar obliquity of TOI-1937A b, a hot Jupiter on a 22.4 hr orbit with the Rossiter–McLaughlin effect, finding the planet’s orbit to be well aligned with the stellar spin axis (∣ λ ∣ = 4.°0 ± 3.°5). We also investigated the possibility that TOI-1937 is a member of the NGC 2516 open cluster but ultimately found the evidence for cluster membership to be ambiguous. These objects are part of a larger effort to build a complete sample of hot Jupiters to be used for future demographic and detailed characterization work.
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Exoplanets - Hot Jupiters - Radial velocity - Exoplanet detection methods - Transit photometry - Astrophysics - QB460-466Content provider:
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
Sèbastien Gaujoux;Nebyou Seyoum;Ville Sallinen;Ari Leppäniemi;Andrea Belli;...
Introduction Surgical site infection (SSI) is one of the most common healthcare-associ...
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
BMJ Global Health, Vol 5, Iss 12 (2020)
Introduction Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.Methods A multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).Results Of 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.Conclusion The odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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Medicine (General) - R5-920 - Infectious and parasitic diseases - RC109-216Content provider:
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Feasibility of reporting results of large randomised controlled trials to participants: experience from the Fluoxetine Or Control Under Supervision (FOCUS) trial
Martin Dennis;D Cohen;A Thompson;Graham Ellis;A Khan;L Hunt;X Huang;J Andre...
Objectives Informing research participants of the results of studies in which they too...
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Feasibility of reporting results of large randomised controlled trials to participants: experience from the Fluoxetine Or Control Under Supervision (FOCUS) trial
BMJ Open, Vol 10, Iss 11 (2020)
Objectives Informing research participants of the results of studies in which they took part is viewed as an ethical imperative. However, there is little guidance in the literature about how to do this. The Fluoxetine Or Control Under Supervision trial randomised 3127 patients with a recent acute stroke to 6 months of fluoxetine or placebo and was published in the Lancet on 5 December 2018. The trial team decided to inform the participants of the results at exactly the same time as the Lancet publication, and also whether they had been allocated fluoxetine or placebo. In this report, we describe how we informed participants of the results.Design In the 6-month and 12-month follow-up questionnaires, we invited participants to provide an email address if they wished to be informed of the results of the trial. We re-opened our trial telephone helpline between 5 December 2018 and 31 March 2019.Setting UK stroke services.Participants 3127 participants were randomised. 2847 returned 6-month follow-up forms and 2703 returned 12-month follow-up forms; the remaining participants had died (380), withdrawn consent or did not respond.Results Of those returning follow-up questionnaires, a total of 1845 email addresses were provided and a further 50 people requested results to be sent by post. Results were sent to all email and postal addresses provided; 309 emails were returned unrecognised. Seventeen people replied, of whom three called the helpline and the rest responded by email.Conclusion It is feasible to disseminate results of large trials to research participants, though only around 60% of those randomised wanted to receive the results. The system we developed was efficient and required very little resource, and could be replicated by trialists in the future.Trial registration number ISRCTN83290762; Post-results.
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Integrated Molecular Characterization of Testicular Germ Cell Tumors
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Cell Reports, Vol 23, Iss 11, Pp 3392-3406 (2018)
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Hui Shen;Juliann Shih;Daniel P. Hollern;Linghua Wang;Reanne Bowlby;Satish K...
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Cell Reports, Vol 23, Iss 11, Pp 3392-3406 (2018)
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Summary: We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensi...
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Integrated Molecular Characterization of Testicular Germ Cell Tumors
Cell Reports, Vol 23, Iss 11, Pp 3392-3406 (2018)
Summary: We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance—KIT, KRAS, and NRAS—exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma. Striking differences in global DNA methylation and microRNA expression between histology subtypes highlight a likely role of epigenomic processes in determining histologic fates in TGCTs. We also identified a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number. We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas. : Shen et al. identify molecular characteristics that classify testicular germ cell tumor types, including a separate subset of seminomas defined by KIT mutations. This provides a set of candidate biomarkers for risk stratification and potential therapeutic targeting. Keywords: The Cancer Genome Atlas, testicular germ cell tumors, seminoma, nonseminoma, DNA methylation, exome sequencing, KIT, copy number, miR-375
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Biology (General) - QH301-705.5Content provider:
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Proceedings of the 14th annual conference of INEBRIA
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Addiction Science & Clinical Practice, Vol 12, Iss S1, Pp 1-24 (2017)
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Aisha S. Holloway;Jennifer Ferguson;Sarah Landale;Laura Cariola;Dorothy New...
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Addiction Science & Clinical Practice, Vol 12, Iss S1, Pp 1-24 (2017)
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Proceedings of the 14th annual conference of INEBRIA
Addiction Science & Clinical Practice, Vol 12, Iss S1, Pp 1-24 (2017)
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Medicine (General) - R5-920 - Social pathology. Social and public welfare. Criminology - HV1-9960Content provider:
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