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I Say, You Say, We Say: Using Spoken Language to Model Socio-Cognitive Processes during Computer-Supported Collaborative Problem Solving
Stewart, Angela E. B.;Vrzakova, Hana;Sun, Chen;Yonehiro, Jade;Stone, Cathly...
Conference Conference | Grantee Submission. 2019Paper presented at the ACM Conference on Computer Supported Cooperative Work (CSCW) (Nov 2019). Please log in to see more details
Collaborative problem solving (CPS) is a crucial 21st century skill; however, current ... more
I Say, You Say, We Say: Using Spoken Language to Model Socio-Cognitive Processes during Computer-Supported Collaborative Problem Solving
Grantee Submission. 2019Paper presented at the ACM Conference on Computer Supported Cooperative Work (CSCW) (Nov 2019).
Collaborative problem solving (CPS) is a crucial 21st century skill; however, current technologies fall short of effectively supporting CPS processes, especially for remote, computer-enabled interactions. In order to develop next-generation computer-supported collaborative systems that enhance CPS processes and outcomes by monitoring and responding to the unfolding collaboration, we investigate automated detection of three critical CPS process -- construction of shared knowledge, negotiation/coordination, and maintaining team function -- derived from a validated CPS framework. Our data consists of 32 triads who were tasked with collaboratively solving a challenging visual computer programming task for 20 minutes using commercial videoconferencing software. We used automatic speech recognition to generate transcripts of 11,163 utterances, which trained humans coded for evidence of the above three CPS processes using a set of behavioral indicators. We aimed to automate the trained human-raters' codes in a team-independent fashion (current study) in order to provide automatic real-time or offline feedback (future work). We used Random Forest classifiers trained on the words themselves (bag of n-grams) or with word categories (e.g., emotions, thinking styles, social constructs) from the Linguistic Inquiry Word Count (LIWC) tool. Despite imperfect automatic speech recognition, the n-gram models achieved AUROC (area under the receiver operating characteristic curve) scores of 0.85, 0.77, and 0.77 for construction of shared knowledge, negotiation/coordination, and maintaining team function, respectively; these reflect 70%, 54%, and 54% improvements over chance. The LIWC-category models achieved similar scores of 0.82, 0.74, and 0.73 (64%, 48%, and 46% improvement over chance). Further, the LIWC model-derived scores predicted CPS outcomes more similar to human codes, demonstrating predictive validity. We discuss embedding our models in collaborative interfaces for assessment and dynamic intervention aimed at improving CPS outcomes. [This paper was published in: "Proceedings of the ACM on Human-Computer Interaction" (ISSN 2573-0142) Vol. 3, Article 194. New York, NY: ACM (Nov 2019).]

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A marked point process approach for identifying neural correlates of tics in Tourette Syndrome
Loza, Carlos A.;Shute, Jonathan B.;Principe, Jose C.;Okun, Michael S.;Gundu...
Conference Conference | 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Engineering in Medicine and Biology Society (EMBC), 2017 39th Annual International Conference of the IEEE. :4375-4378 Jul, 2017 Please log in to see more details

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Scheduled, intermittent stimulation of the thalamus reduces tics in Tourette syndrome
Rossi, P. Justin;Opri, Enrico;Shute, Jonathan B.;Molina, Rene;Bowers, Dawn;...
Academic Journal Academic Journal | In Parkinsonism and Related Disorders August 2016 29:35-41 Please log in to see more details

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Vector recording in perpendicular media
Miles, J.;Wood, R.;Olson, T.;Shute, H.;Wilton, D.;Middleton, B.
Academic Journal Academic Journal | IEEE Transactions on Magnetics IEEE Trans. Magn. Magnetics, IEEE Transactions on. 38(5):2060-2062 Sep, 2002 Please log in to see more details

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Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1
John T. Melchior;Scott E. Street;Allison B. Andraski;Jeremy D. Furtado;Fran...
Academic Journal Academic Journal | Journal of Lipid Research, Vol 58, Iss 7, Pp 1374-1385 (2017) Please log in to see more details
HDLs are a family of heterogeneous particles that vary in size, composition, and funct... more
Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1
Journal of Lipid Research, Vol 58, Iss 7, Pp 1374-1385 (2017)
HDLs are a family of heterogeneous particles that vary in size, composition, and function. The structure of most HDLs is maintained by two scaffold proteins, apoA-I and apoA-II, but up to 95 other “accessory” proteins have been found associated with the particles. Recent evidence suggests that these accessory proteins are distributed across various subspecies and drive specific biological functions. Unfortunately, our understanding of the molecular composition of such subspecies is limited. To begin to address this issue, we separated human plasma and HDL isolated by ultracentrifugation (UC-HDL) into particles with apoA-I and no apoA-II (LpA-I) and those with both apoA-I and apoA-II (LpA-I/A-II). MS studies revealed distinct differences between the subfractions. LpA-I exhibited significantly more protein diversity than LpA-I/A-II when isolated directly from plasma. However, this difference was lost in UC-HDL. Most LpA-I/A-II accessory proteins were associated with lipid transport pathways, whereas those in LpA-I were associated with inflammatory response, hemostasis, immune response, metal ion binding, and protease inhibition. We found that the presence of apoA-II enhanced ABCA1-mediated efflux compared with LpA-I particles. This effect was independent of the accessory protein signature suggesting that apoA-II induces a structural change in apoA-I in HDLs.

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proteomics - high density lipoprotein/structure - ATP binding cassette transporter A1 - Biochemistry - QD415-436

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Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
Ge Li;Jane B. Shofer;Eric C. Petrie;Chang-En Yu;Charles W. Wilkinson;Dianne...
Academic Journal Academic Journal | Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-9 (2017) Please log in to see more details
Abstract Background This study sought to evaluate gender and APOE genotype-related dif... more
Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-9 (2017)
Abstract Background This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) and cerebrovascular injury across the life span of cognitively normal adults. Methods CSF amyloid beta1–42 (Aβ42), phospho-tau-181 (p-tau181), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF E-selectin and vascular cell adhesion protein 1 (VCAM1) were measured in 249 participants who were between the ages of 50 and 100. Results CSF total tau and p-tau181 increased with age over the adult life span (p

Subject terms:

Alzheimer’s disease - Cerebrovascular disease - Cerebrospinal fluid - Biomarkers - Age - Gender - Neurosciences. Biological psychiatry. Neuropsychiatry - RC321-571 - Neurology. Diseases of the nervous system - RC346-429

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Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
Jonathan B. Shute;Michael S. Okun;Enrico Opri;Rene Molina;P. Justin Rossi;D...
Academic Journal Academic Journal | NeuroImage: Clinical, Vol 12, Iss C, Pp 165-172 (2016) Please log in to see more details
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor ... more
Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
NeuroImage: Clinical, Vol 12, Iss C, Pp 165-172 (2016)
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Deep brain stimulation (DBS) is an emerging therapy for severe cases of TS. We studied two patients with TS implanted with bilateral Medtronic Activa PC + S DBS devices, capable of chronic recordings, with depth leads in the thalamic centromedian–parafascicular complex (CM-PF) and subdural strips over the precentral gyrus. Low-frequency (1–10 Hz) CM-PF activity was observed during tics, as well as modulations in beta rhythms over the motor cortex. Tics were divided into three categories: long complex, complex, and simple. Long complex tics, tics involving multiple body regions and lasting longer than 5 s, were concurrent with a highly detectable thalamocortical signature (average recall [sensitivity] 88.6%, average precision 96.3%). Complex tics were detected with an average recall of 63.9% and precision of 36.6% and simple tics an average recall of 39.3% and precision of 37.9%. The detections were determined using data from both patients.

Subject terms:

Tourette syndrome - Centromedian thalamus - Motor cortex - Deep brain stimulation - Computer applications to medicine. Medical informatics - R858-859.7 - Neurology. Diseases of the nervous system - RC346-429

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Impact of hot and cold exposure on human skeletal muscle gene expression
Zak, Roksana B.;Shute, Robert J.;Heesch, Matthew W.S.;La Salle, D. Taylor;B...
Academic Journal Academic Journal | Applied Physiology, Nutrition, and Metabolism. March 2017, Vol. 42 Issue 3, p319, 7 p. Please log in to see more details

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Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank - A Review of Emerging Issues and Technologies
Wissam Deeb;James J Giordano;Peter Justin Rossi;Alon Mogilner;Aysegul Gundu...
Academic Journal Academic Journal | Frontiers in Integrative Neuroscience, Vol 10 (2016) Please log in to see more details
This paper provides an overview of current progress in the technological advances and ... more
Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank - A Review of Emerging Issues and Technologies
Frontiers in Integrative Neuroscience, Vol 10 (2016)
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual Deep Brain Stimulation Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome. Next, advances in the use of neuroimaging and electrochemical markers to enhance DBS specificity were addressed. Updates on ongoing use and developments of DBS for the treatment of Parkinson’s disease, essential tremor, Alzheimer’s disease, depression, post-traumatic stress disorder, obesity, addiction were presented, and progress toward innovation(s) in closed-loop applications were discussed. Each section of these proceedings provides updates and highlights of new information as presented at this year’s international Think Tank, with a view toward current and near future advancement of the field.

Subject terms:

Alzheimer Disease - Depression - Parkinson Disease - Tourette Syndrome - Neuromodulation - deep brain stimulation (DBS) - Neurosciences. Biological psychiatry. Neuropsychiatry - RC321-571 - Neurology. Diseases of the nervous system - RC346-429

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Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
Li, Ge;Shofer, Jane B.;Petrie, Eric C.;Yu, Chang-En;Wilkinson, Charles W.;F...
Academic Journal Academic Journal | Alzheimer's Research & Therapy. July 3, 2017, Vol. 9 Issue 1 Please log in to see more details

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1994 BLACK ENGINEER OF THE YEAR AWARD
Kastre, Michael F.;Prothro, Gerald D.;Johnson, Barry;Prather,, Thomas Levi;...
Academic Journal Academic Journal | US Black Engineer, 1994 Jan 01. 18(1), 39-53. Please log in to see more details

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Problems
Propp, James;Sastry, K. R. S.;Johnson,, Allan W.;Ecker, Michael W.;Friedlan...
Academic Journal Academic Journal | Mathematics Magazine, 1977 May 01. 50(3), 163-169. Please log in to see more details
Prioritizing countries for interventions to reduce child mortality: tools for maximizing the impact of mass drug administration of azithromycin.
Alastair I Matheson;Lisa E Manhart;Patricia B Pavlinac;Arianna R Means;Adam...
Academic Journal Academic Journal | PLoS ONE, Vol 9, Iss 5, p e96658 (2014) Please log in to see more details
BACKGROUND: As new interventions to reduce childhood mortality are identified, careful... more
Prioritizing countries for interventions to reduce child mortality: tools for maximizing the impact of mass drug administration of azithromycin.
PLoS ONE, Vol 9, Iss 5, p e96658 (2014)
BACKGROUND: As new interventions to reduce childhood mortality are identified, careful consideration must be given to identifying populations that could benefit most from them. Promising reductions in childhood mortality reported in a large cluster randomized trial of mass drug administration (MDA) of azithromycin (AZM) prompted the development of visually compelling, easy-to-use tools that synthesize country-specific data on factors that would influence both potential AZM benefit and MDA implementation success. METHODOLOGY/PRINCIPAL FINDINGS: We assessed the opportunity to reduce mortality and the feasibility of implementing such a program, creating Opportunity and Feasibility Indices, respectively. Countries with high childhood mortality were included. A Country Ranking Index combined key variables from the previous two Indices and applied a scoring system to identify high-priority countries. We compared four scenarios with varying weights given to each variable. Twenty-five countries met inclusion criteria. We created easily visualized tools to display the results of the Opportunity and Feasibility Indices. The Opportunity Index revealed substantial variation in the opportunity for an MDA of AZM program to reduce mortality, even among countries with high overall childhood mortality. The Feasibility Index demonstrated that implementing such a program would be most challenging in the countries that could see greatest benefit. Based on the Country Ranking Index, Equatorial Guinea would benefit the most from the MZA of AZM in three of the four scenarios we tested. CONCLUSIONS/SIGNIFICANCE: These visually accessible tools can be adapted or refined to include other metrics deemed important by stakeholders, and provide a quantitative approach to prioritization for intervention implementation. The need to explicitly state metrics and their weighting encourages thoughtful and transparent decision making. The objective and data-driven approach promoted by the three Indices may foster more efficient use of resources.

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Medicine - Science

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Reflecting on the Past: A Content Analysis of Family Therapy Research from 2000-2015.
Lambert‐Shute, Jennifer J.;Nguyen, Hoa N.;Peterson, Paul W.;Pirasteh, Annis...
Academic Journal Academic Journal | Journal of Marital Apr2019, Vol. 45 Issue 2, p256-274, 19p, 1 Diagram, 2 Charts, 4 Graphs Please log in to see more details

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Lifetime of the 961 keV 1 - Level in 152 Sm
Shute, G. G.;Sood, B. S.
Academic Journal Academic Journal | Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences, 1960 Aug . 257(1288), 52-58. Please log in to see more details
LETTERS.
BRICKER, JOHN W.;FIELD, ARTHUR G.;STANTON, ROGER;MILES, VIVIEN;ROGERS, HOWA...
Periodical Periodical | TIME Magazine. 8/3/1953, Vol. 62 Issue 5, p2-4. 3p. Please log in to see more details

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Coagulation factors in the airways in moderate and severe asthma and the effect of inhaled steroids
Brims, F.J.H.;Chauhan, A.J.;Higgins, B.;Shute, J.K.
Periodical Periodical | Thorax. Dec 2009, Vol. 64 Issue 12, p1037, 7 p. Please log in to see more details

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Prioritizing Countries for Interventions to Reduce Child Mortality: Tools for Maximizing the Impact of Mass Drug Administration of Azithromycin
Matheson, Alastair I.;Manhart, Lisa E.;Pavlinac, Patricia B.;Means, Arianna...
Academic Journal Academic Journal | PLoS ONE. May 16, 2014, Vol. 9 Issue 5 Please log in to see more details

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Obtaining an understanding of environmental knowledge: Wendaban Stewardship Authority
Shute, Jeremy J.;Knight, David B.
Academic Journal Academic Journal | The Canadian Geographer. Summer, 1995, Vol. 39 Issue 2, p101, 11 p. table Please log in to see more details

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