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Rubber [electronic resource] / directed by Mimi Soeteman, Lee Thean-Jeje, and Karan Low.
Streaming video | 2011
Available at Available Online Academic Video Online (USU and USU Eastern) (Call number: Streaming Video)
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Location Call No. Status
Online Academic Video Online (USU and USU Eastern) Streaming Video Available

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Rubber : sampling and testing.
Government Document | 1955 -
Available at Available Merrill-Cazier Government Documents (Lower Level) (Call number: GS 2.8/7:601/)

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Rubber / by Edith A. Browne, F.R.G.S., containing twenty-four pages of illustrations from photographs.
Book | 1912
Available at Available Merrill-Cazier Books (4th Floor North) (Call number: SB 291 .I4 B85 1912)

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Development of biodegradable packaging films from carboxymethyl cellulose and oxidised natural rubber latex.
Viswanathan VP;Kulandhaivelu SV;Manivasakan K;Ramakrishnan R
Academic Journal Academic Journal | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE Please log in to see more details
The present study investigates the biopolymer packaging film developed from carboxymet... more
Development of biodegradable packaging films from carboxymethyl cellulose and oxidised natural rubber latex.
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
The present study investigates the biopolymer packaging film developed from carboxymethyl cellulose (CMC) with varying concentrations of natural rubber latex (NR) and oxidised natural rubber latex (ONR) using the solvent casting method. The physicochemical properties of the CMC/NR and CMC/ONR film samples were characterised using FTIR, TG/DTA, DSC, SEM, and XRD analysis. The increased concentration of NR and ONR helped to enhance mechanical characteristics, superior UV resistance, enhanced resistance to oxygen and water vapour penetration, improved dimensional stability, and a reduction in the moisture retention ability of the film samples. The CMC sample film, incorporated with 1.5 g ONR, was found to have more than a 100 % increase in the tensile strength. The tensile value increased from 21.56 MPa to 48.36 MPa, with the highest young modulus of 0.73 GPa and elastic stability of 7.14 %. The incorporation of NR and ONR significantly reduced the super water absorbency nature of the CMC film, and the moisture content values reduced from 21.6 % to ≅ 0.15 % for ONR-incorporated film. Additionally, the CMC/NR and CMC/ONR films exhibited high optical transparency values and were found to be fast biodegradable, substantiating their potential use in various packaging applications. Application of these materials in perishable fruit packaging has shown significant enhancement in shelf life, highlighting their practical efficiency and potential for sustainable packaging solutions.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)

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Latex - Product Packaging - Drug Packaging - Food Packaging - Rubber chemistry - Carboxymethylcellulose Sodium chemistry

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MEDLINE

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An overview on waste rubber recycling by microwave devulcanization.
Zhang T;Asaro L;Gratton M;Aït Hocine N
Academic Journal Academic Journal | Publisher: Academic Press Country of Publication: England NLM ID: 0401664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8630 (Electronic) Linking ISSN: 03014797 NLM ISO Abbreviation: J Environ Manage Subsets: MEDLINE Please log in to see more details
This review deals with waste rubber recycling by devulcanization treatment using micro... more
An overview on waste rubber recycling by microwave devulcanization.
Publisher: Academic Press Country of Publication: England NLM ID: 0401664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8630 (Electronic) Linking ISSN: 03014797 NLM ISO Abbreviation: J Environ Manage Subsets: MEDLINE
This review deals with waste rubber recycling by devulcanization treatment using microwave method. In fact, vulcanized rubbers have been extensively used in various fields due to their superior performances. Subsequently, the massive use of such materials, especially in the automotive industry, has generated a substantial amount of wastes which are not easily to be degraded due to the three-dimensional network formed by the vulcanization process. One of the optimal solutions for the successful recycling of rubber is devulcanization, i.e., the process in which the sulfur bonds in the vulcanized material are selectively broken. Currently, to achieve rubber devulcanization, the microwave treatment has been proposed as a promising alternative process due to its precise manipulation of process variables. Furthermore, the microwave process is easily to be coupled with effects of other elements such as chemical and swelling agents. In this work, different microwave devulcanization methods are reviewed, the utilization of the corresponding devulcanized materials has also been discussed. The reviewed contents are believed to be of great interest to academics and industries since they represent a great challenge from scientific, economic and environmental points of view.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Tao Zhang reports financial support was provided by China Scholarship Council. Tao Zhang reports a relationship with China Scholarship Council that includes: funding grants.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)

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Recycling methods - Rubber chemistry - Rubber metabolism - Microwaves

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MEDLINE

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Cleavage of natural rubber by rubber oxygenases in Gram-negative bacteria.
Prakash T;Yadav SR;Bürger M;Jendrossek D
Academic Journal Academic Journal | Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0614 (Electronic) Linking ISSN: 01757598 NLM ISO Abbreviation: Appl Microbiol Biotechnol Subsets: MEDLINE Please log in to see more details
Bacterial degradation of natural rubber (NR) in an oxic environment is initiated by ox... more
Cleavage of natural rubber by rubber oxygenases in Gram-negative bacteria.
Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0614 (Electronic) Linking ISSN: 01757598 NLM ISO Abbreviation: Appl Microbiol Biotechnol Subsets: MEDLINE
Bacterial degradation of natural rubber (NR) in an oxic environment is initiated by oxidative cleavage of double bonds in the NR-carbon backbone and is catalyzed by extracellular haem-containing rubber oxygenases. NR-cleavage products of sufficiently low molecular mass are taken up by the cells and metabolized for energy and biomass formation. Gram-negative and Gram-positive NR-degrading bacteria (usually) employ different types of rubber oxygenases such as RoxA and/or RoxB (most Gram-negative NR-degraders) or latex clearing protein Lcp (most Gram-positive NR-degraders). In order to find novel orthologues of Rox proteins, we have revisited databases and provide an update of Rox-like proteins. We describe the putative evolution of rubber oxygenases and confirm the presence of a third subgroup of Rox-related proteins (RoxCs), the biological function of which remains, however, unclear. We summarize the knowledge on the taxonomic position of Steroidobacter cummioxidans 35Y and related species. Comparison of genomic and biochemical features of strain 35Y with other species of the genus Steroidobacter suggests that strain 35Y represents a species of a novel genus for which the designation Aurantibaculum gen. nov. is proposed. A short summary on the capabilities of NR-degrading consortia, that could be superior in biotechnological applications compared to pure cultures, is also provided. KEY POINTS: • Three types of rubber oxygenases exist predominantly in Gram-negative microbes • S. cummioxidans 35Y contains RoxA and RoxB which are superior in activity • S. cummioxidans 35Y represents a species of a novel genus.
(© 2024. The Author(s).)

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Bacterial Proteins metabolism - Latex metabolism - Gram-Negative Bacteria genetics - Gram-Negative Bacteria metabolism - Rubber metabolism - Oxygenases metabolism

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MEDLINE

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Creating with paper tubes, rubber bands & yarn / Elsie Olson.
Book | 2022
Available at Available Moore Library, Non-Fiction Books (Call number: 745.5 OLS)
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Moore Library, Non-Fiction Books 745.5 OLS Available

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Assessment of the effect of different pulping by-products on enhancing the reuse of rubber waste in producing of cement-mortar.
Lotfy VF;Basta AH;Shafik ES
Academic Journal Academic Journal | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE Please log in to see more details
This work deals with avoiding the pollution risks from paper pulping liquors and rubbe... more
Assessment of the effect of different pulping by-products on enhancing the reuse of rubber waste in producing of cement-mortar.
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
This work deals with avoiding the pollution risks from paper pulping liquors and rubber wastes that result from routine disposal tools; moreover, finding an approach to minimize the drawback of incorporating the rubber waste in weakening the strength of building materials. In this respect, pulping black liquors (BLs) is assessed as a treating agent for rubber waste and substituting the water in cement mortar formulation. The assessment was achieved by testing the mechanical properties, water resistance (reduction in water absorption and dimensional change against water), and morphology. The results showed that all BLs from different pulping agents, used in mixtures with water, provided improvements in both strength and water resistance properties. Kraft black liquor is most effective in providing improvements in compressive strength and flexural strength, as well as resistance to water absorption and change in dimension after exposure to water for 24 h, where the improvements were 688.2 %, 494.3 %, 27 %, and 65.3 %, respectively. It is interesting to note that this investigated route provided improvements in the impact resistance property of mortar. This last property is essential for minimizing accidents on the highway.
Competing Interests: Declaration of competing interest Authors declare that there is no conflict among the contributing author related to the financial or non-financial interests that are directly or indirectly related to the work submitted for publication.
(Copyright © 2023 Elsevier B.V. All rights reserved.)

Subject terms:

Construction Materials - Compressive Strength - Water - Rubber - Environmental Pollution

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MEDLINE

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Advancing automobile identification and brand discrimination from tyre rubber through Machine learning algorithms for forensic investigations.
Kaur N;Sharma A;Sharma V
Academic Journal Academic Journal | Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE Please log in to see more details
Criminal instances involving collision accidents, hit-and-run incidents, abduction, ho... more
Advancing automobile identification and brand discrimination from tyre rubber through Machine learning algorithms for forensic investigations.
Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE
Criminal instances involving collision accidents, hit-and-run incidents, abduction, hostage-taking, and the unauthorised transit of forbidden items generally include evidence involving rubber traces from automobile tyres. These traces can be located on the road surface, in clothing, on the victim(s) themselves, or on items as skid marks following sudden stopping and spinning around. These traces serve as crucial evidence by reducing the range of suspects by revealing linkages between the getaway vehicle, the site of the crime, and the perpetrator through the tyre's brand, producer, or origin. This study offered a way for classifying 220 tyre rubber samples from different brands using various machine learning algorithms in PyCaret in conjunction with rapid and non-destructive ATR-FTIR spectroscopy equipped with diamond crystal. On spectral information from ATR-FTIR, pre-processing tools such as baseline correction, smoothing, derivatization, and normalisation were also implemented prior to machine learning. This approach has the potential to be advantageous for efficiently and non-destructively identifying rubber traces as forensic evidence and for facilitating brand recognition of automobile tyres.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)

Subject terms:

Spectroscopy, Fourier Transform Infrared - Automobiles - Rubber

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MEDLINE

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Preparation of UV-cured cellulose nanocrystal-filled epoxidized natural rubber and its application in a triboelectric nanogenerator.
Somseemee O;Siriwong K;Sae-Oui P;Harnchana V;Appamato I;Prada T;Siriwong C
Academic Journal Academic Journal | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE Please log in to see more details
Cellulose nanocrystal (CNC) is an abundant biopolymer possessing high strength and bio... more
Preparation of UV-cured cellulose nanocrystal-filled epoxidized natural rubber and its application in a triboelectric nanogenerator.
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Cellulose nanocrystal (CNC) is an abundant biopolymer possessing high strength and biodegradability. In the present work, the extraction of CNCs from Napier grass stems was carried out. The CNCs were subsequently modified by maleic anhydride, called M-CNC, before being incorporated into the epoxidized natural rubber (ENR). The compounds were later cured by ultraviolet (UV) irradiation under various conditions. The obtained optimum condition was then used to fabricate the biocomposites filled with various CNC and M-CNC loadings for triboelectric nanogenerator (TENG) performance measurements. Output voltage and current increased continuously with increasing filler loading. Regardless of the filler type, an increase in filler loading enhanced TENG output. ENR/M-CNC exhibited a superior TENG output to ENR/CNC due to the greater electron transfer capability of the biocomposites, as proven by the reduction in the ionization potential (IP) value obtained from the quantum calculation. In this study, ENR/M-CNC5 exhibited the maximum output voltage (80.3 V), current (7.4 μA), and power density (1.32 W/m 2 ) at a load resistance of 9 MΩ.
Competing Interests: Declaration of competing interest There is no conflict of interests to declare.
(Copyright © 2024 Elsevier B.V. All rights reserved.)

Subject terms:

Cellulose - Cinacalcet - Electron Transport - Excipients - Rubber - Nanoparticles

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MEDLINE

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Management of ground tire rubber waste by incorporation into polyurethane-based composite foams.
Hejna A;Kosmela P;Olszewski A;Zedler Ł;Formela K;Skórczewska K;Piasecki A;M...
Academic Journal Academic Journal | Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE Please log in to see more details
Rapid economic growth implicated the developing multiple industry sectors, including t... more
Management of ground tire rubber waste by incorporation into polyurethane-based composite foams.
Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
Rapid economic growth implicated the developing multiple industry sectors, including the automotive branch, increasing waste generation since recycling and utilization methods have not been established simultaneously. A very severe threat is the generation of enormous amounts of post-consumer tires considered burdensome waste, e.g., due to the substantial emissions of volatile organic compounds (VOCs). Therefore, it is essential to develop novel, environmentally friendly methods for their utilization, which would hinder their environmental impacts. One of the most promising approaches is shredding, resulting in the generation of ground tire rubber (GTR), which can be introduced into polymeric materials as filler. The presented work is related to the thermomechanical treatment of GTR in a twin-screw extruder with zinc borate, whose incorporation is aimed to enhance shear forces within the extruder barrel. Modified GTR was introduced into flexible polyurethane (PU) foams, and the impact of modification parameters on the cellular structure, static and dynamic mechanical performance, thermal stability, as well as thermal insulation, and acoustic properties was investigated. Emissions of VOCs from applied fillers and prepared composites were monitored and evaluated. Depending on the treatment parameters, beneficial changes in foams' cellular structure were noted, which enhanced their thermal insulation performance, mechanical strength, and thermal stability. It was proven that the proposed method of GTR thermomechanical treatment assisted by zinc borate particles might benefit the performance of flexible PU foamed composites and hinder VOC emissions, which could broaden the application range of GTR and provide novel ways for its efficient utilization.
(© 2023. The Author(s).)

Subject terms:

Polyurethanes - Zinc - Rubber - Borates

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MEDLINE

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Non-targeted analysis based on quantitative prediction and toxicity assessment for emerging contaminants in tire particle leachates.
Li Y;Lu Z;Zhang X;Wang J;Zhao S;Dai Y
Academic Journal Academic Journal | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE Please log in to see more details
Non-targeted analysis (NTA) has great potential to screen emerging contaminants in the... more
Non-targeted analysis based on quantitative prediction and toxicity assessment for emerging contaminants in tire particle leachates.
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE
Non-targeted analysis (NTA) has great potential to screen emerging contaminants in the environment, and some studies have conducted in-depth investigation on environmental samples. Here, we used a NTA workflow to identify emerging contaminants in used tire particle (TP) leachates, followed by quantitative prediction and toxicity assessment based on hazard scores. Tire particles were obtained from four different types of automobiles, representing the most common tires during daily transportation. With the instrumental analysis of TP leachates, a total of 244 positive and 104 negative molecular features were extracted from the mass data. After filtering by a specialized emerging contaminants list and matching by spectral databases, a total of 51 molecular features were tentatively identified as contaminants, including benzothiazole, hexaethylene glycol, 2-hydroxybenzaldehyde, etc. Given that these contaminants have different mass spectral responses in the mass spectrometry, models for predicting the response of contaminants were constructed based on machine learning algorithms, in this case random forest and artificial neural networks. After five-fold cross-validation, the random forest algorithm model had better prediction performance (MAE CV  = 0.12, Q 2  = 0.90), and thus it was chosen to predict the contaminant concentrations. The prediction results showed that the contaminant at the highest concentration was benzothiazole, with 4,875 μg/L in the winter tire sample. In addition, the joint toxicity assessment of four types of tires was conducted in this study. According to different hazard levels, hazard scores increasing by a factor 10 were developed, and hazard scores of all the contaminants identified in each TP leachate were summed to obtain the total hazard score. All four tires were calculated to have relatively high risks, with winter tires having the highest total hazard score of 40,751. This study extended the application of NTA research and led to the direction of subsequent targeting studies on highly concentrated and toxic contaminants.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)

Subject terms:

Transportation - Benzothiazoles toxicity - Rubber chemistry - Rubber toxicity - Automobiles

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MEDLINE

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The European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit.
Zuccaro P;Thompson DC;de Boer J;Llompart M;Watterson A;Bilott R;Birnbaum LS...
Academic Journal Academic Journal | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE Please log in to see more details
The European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit.
Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE

Subject terms:

Plastics - European Union - Environmental Exposure analysis - Rubber - Microplastics

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MEDLINE

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Preparation and modification mechanism study of microwave-treated crumb rubber and waste engine oil-modified asphalt.
Chen Y;Hu K;Chen Y;Zhang T;Zhang W
Academic Journal Academic Journal | Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE Please log in to see more details
The objective of this study was to characterize the performance of waste engine oil (W... more
Preparation and modification mechanism study of microwave-treated crumb rubber and waste engine oil-modified asphalt.
Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
The objective of this study was to characterize the performance of waste engine oil (WEO) and microwave-treated crumb rubber (CR)-modified asphalt (WEO-MCRA) and analyze the modification mechanism. The viscosity and dynamic shear rheological (DSR) tests were carried out to evaluate the viscoelasticity property of WEO-MCRA. The storage stability and fluorescence microscope (FM) tests were used to characterize the compatibility of the components. The Fourier transform infrared spectroscopy (FTIR) and molecular dynamic simulation were introduced to analyze the change of function groups and modification mechanism. The results demonstrated that introducing Wt.20% CR treated with microwave and Wt.6% WEO obtained a lower viscosity, excellent storage stability, and satisfactory elasticity properties of asphalt. The morphology of modifiers presented a thread-like structure microscopic with the range of WEO content Wt.3%-Wt.6%. Molecular dynamic simulations revealed that the aromatic may be intensively absorbed by CR and increase the likelihood of phase separation. WEO reduced the binding energy of CR to aromatic from 178.0 to 151.5 kcal/mol, which will contribute to the disaggregation of CR clusters. The diffusion coefficient shows a more obvious decrease with the addition of WEO and microwave treatment, which will benefit the stability of the asphalt. This study can provide a reference for the recycling of CR and WEO.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Subject terms:

Elasticity - Hydrocarbons - Microwaves - Rubber

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MEDLINE

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Comparing the wound healing potential of natural rubber latex serum and F1-protein: An in vivo approach.
Morais PCR;Floriano JF;Garcia CGP;Chagas ALD;Mussagy CU;Guerra NB;Sant'Ana ...
Academic Journal Academic Journal | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE Please log in to see more details
Chronic wounds pose significant health concerns. Current treatment options include nat... more
Comparing the wound healing potential of natural rubber latex serum and F1-protein: An in vivo approach.
Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE
Chronic wounds pose significant health concerns. Current treatment options include natural compounds like natural rubber latex (NRL) from Hevea brasiliensis. NRL, particularly the F1 protein fraction, has demonstrated bioactivity, biocompatibility, and angiogenic effects. So far, there is no study comparing F1 protein with total NRL serum, and the necessity of downstream processing remains unknown. Here, we evaluated the angiogenic potential of F1 protein compared to total NRL serum and the need for downstream processing. For that, ion exchange chromatography (DEAE-Sepharose), antioxidant activity, physicochemical characterization, cell culture in McCoy fibroblasts, and wound healing in Balb-C mice were performed. Also, the evaluation of histology and collagen content and the levels of inflammatory mediators were quantified. McCoy fibroblast cell assay showed that F1 protein (0.01 %) and total NRL serum (0.01 %) significantly increased cell proliferation by 47.1 ± 11.3 % and 25.5 ± 2.5 %, respectively. However, the AA of F1 protein (78.9 ± 0.8 %) did not show a significant difference compared to NRL serum (77.0 ± 1.1 %). F1 protein and NRL serum were more effective in wound management in rodents. Histopathological analysis confirmed accelerated healing and advanced tissue repair. Similarly, the F1 protein (0.01 %) increased collagen, showing that this fraction can stimulate the synthesis of collagen by fibroblastic cells. Regarding cytokines production (IL-10, TNF-α, IFN-γ), F1 protein and NRL serum did not exert an impact on the synthesis of these cytokines. Furthermore, we did not observe statistically significant changes in dosages of enzymes (MPO and EPO) among the groups. Nevertheless, Nitric Oxide dosage was reduced drastically when the F1 protein (0.01 %) protein was applied topically. These findings contribute to the understanding of F1 protein and NRL serum properties and provide insights into cost-effectiveness and practical applications in medicine and biotechnology. Therefore, further research is needed to assess the economic feasibility of downstream processing for NRL-based herbal medicine derived from Hevea brasiliensis.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest, financial or otherwise.
(Copyright © 2023 Elsevier B.V. All rights reserved.)

Subject terms:

Animals - Mice - Latex - Wound Healing - Collagen - Cytokines - Rubber - Hevea chemistry

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MEDLINE

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